One of the main characteristics of the growth hormone is large-sleep secretion. This mainly occurs next to the onset of the slow-wave sleep. In the nighttime secretion, it accounts for almost about seventy percent of the daily growth hormone secretory output in most males.
And, the so-called nocturnal pulse believed to be sexually dimorphic in its nature. In addition to that, it believes to be less pronounced in the majority of women.
Specific Timing Protocol
Due to the very reason that this is a substantial endogenous secretory situation, those who would want to maximize their so-called exogenous growth hormone usage speculate that a specific timing protocol can be utilized to protect the nocturnal secretion. But, the question still remains if the hypothesis has still any merit, so far?
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Growth Hormone as The Target of Many Negative Feedback Loops:
Just like the endocrine systems, the secretion of growth hormone is the target of many negative feedback loops. They are also conventionally divided into 3 main categories like long, short and ultrashort feedbacks.
Prior to the so-called ultra-short feedback loop, it has consisted of the GHRH or the Growth Hormone Releasing Hormone. This acutely inhibits its specific secretion including a somatostatin that suppresses its specific release.
Short Kind of Feedback Loops Consisted of Elevated Levels of Serum GH:
In regard to the short kind of feedback loops, they basically consist of some elevated levels of serum GH. They act directly upon the so-called pituitary gland. That way, they will inhibit some more growth hormone release by way of a suppressed GHRH.
An elevated serum growth hormone actually induces GHRH and SRIF inhibition in the hypothalamus. Considering the effect, there seemed to appear a time delay. This is due to the very reason that some trials presented this specific feedback loop.
This could take between 2 to 4 hours to finally set in. This is believed to be the particular feedback loop that people are most concerned about.
As part of completeness, the feedback loop that is the longest occurs as the elevated serum of IGF-1 levels functions in the pituitary. This way, it will decrease the growth hormone secretion events.
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First Human Trial Conducted to Help Answer The Question:
There were actually 2 human trials conducted to help answer the question. As per the first trial conducted, female and male subjects were subjected. They were provided with 2IUs every day of the so-called exogenous growth hormone that is divided into the morning of about (0800) and in the afternoon of about (1700) injection.
Even if the last growth hormone was administered over the 6 hours because of sleep, the team also noticed a significant suppression of the endogenous secretions.
This is also even if there is an elevated growth hormone. This only means to say that a feedback mechanism behind the effects of growth hormone in itself could be at work.
Second Human Trial Conducted to Help Answer the Question:
As per the 2nd trial, it consists of healthy male subjects. They were provided with a specific subcutaneous dose of about 20kDA growth hormone at about 2100.
In regard to the dose, it was actually varied. The subjects were also divided into specific dosing groups like 0.01, 0.1, 0.05 and 0.025 milligrams/kilograms.
After several hours, all of the dosing groups were found to have suppressed their endogenous growth hormone secretions between sixteen to twenty-four hours.
RHGH Users Must Not Stay as Hyper-Focus:
The point in the trials is that RHGH users should not just hyper-focus on keeping their nocturnal pulse alive. If there will be an exogenous dose of RHGH, there will also be an increase in the possibilities of it being suppressed.
Unless one will use growth hormone strictly for the sake of lipolysis, the so-called evening pulse will not provide an additional effect.
This is because of how it’s actually by structure. It recommends focussing more on the main dosing strategy guidelines.
Growth Hormone Suppression Could Last For About Eighteen to Twenty-Four Hours:
The growth hormone suppression could actually last for about eighteen to twenty-four hours. In the event that you think of using a five day on two days off schedule, you will more likely be suppressed for the next day.
It will be a good idea to follow a seven-day schedule that is beneficial. In the event that there is suppression, it does not actually mean that the growth hormone levels will stay elevated for that long time.
It also shows that the endogenous suppression will more likely occur beyond that particular time that the growth hormone has already cleared the system.
Protocol Like 5/2 Developed Because of Budgetary Issues:
The thoughts of other people highlighted that the protocols like 5/2 developed out of the sake of budgetary issues. Also wondered by many if these could utilize to sensitize the intracellular pathways. It is just that it wonders if desensitization is acute in nature. This may not anymore quire a complete day off.
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Now, you have learned more about the exogenous growth hormone and nocturnal secretions.